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KMID : 0370219970410040399
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Yakhak Hoeji
1997 Volume.41 No. 4 p.399 ~ p.406
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Prejunctional Modulation of Non-adrenergic Non-cholinergic Relaxation of the Rabbit Proximal Stomach by Potassium Channels
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홍은주/Hong EJ
박미선/박상일/김명우/최수경/홍승철/Park MS/Park SI/Kim MW/Choi SK/Hong SC
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Abstract
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The effects of different K+ channel blockers were investigated on the non-adrenergic non-cholinergic (NANC) relaxations in the circular muscle of the rabbit proximal stomach. Non-selective blockers of K+ channels, 4-aminopyridine (4-AP, 3~30mcM) and tetraethylammonium (TEA, 100~1000mcM) significantly enhanced the NANC relaxations in a concentration-dependent manner. The enhancement was more prominent for the NANC relaxations induced by the electric field stimulation (EFS) with lower frequencies. Blockers of large conductance Ca2+-activated K+ channels, charybdotoxin and iberiotoxin, a blocker of small conduntance Ca2+-activated K+ channels, apamin and a blocker of ATP-sensitive K+ channels, glibenclamide had no effect on the NANC relaxations, respectively. Exogeneous administration of nitric oxide (NO, 1~30mcM) caused concentration-dependent relaxations which showed a similarity to those obtained with EFS. None of the K+ channel blockers had an effect on the concentration-dependent relaxation in response to NO. These results suggest that prejunctional K+ channels regulate the release of NO from the NANC nerve in the rabbit proximal stomach as the inhibition of prejunctional K+ channels increases the NANC relaxation induced by the EFS.
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